Heartworm, Worming and Flea Spot-On for Large Dogs

Overview
PURINA Totalcare® Heartworm, Worming & Flea Spot-On Protection for Large Breeds is a topical, all-in-one parasite treatment designed specifically for large dogs. The formulation combines imidacloprid and moxidectin, providing coverage against fleas, heartworm and common intestinal worms in a single monthly application.
Imidacloprid acts on contact to kill adult fleas and larvae, helping break the flea lifecycle, while moxidectin works systemically to prevent heartworm disease and treat intestinal worms such as roundworms, hookworms and whipworms. The liquid is applied directly to the skin as a simple spot-on dose.
This product offers a convenient multi-parasite protection option for large-breed dogs and forms part of the PURINA® TOTALCARE® parasite-management range.
Ingredients
Active: Imidacloprid, Moxidectin. Inactive: Not publicly documented.

Imidacloprid is a neonicotinoid insecticide used in topical flea treatments for dogs. It acts on the nervous system of fleas by binding to nicotinic acetylcholine receptors, causing paralysis and death within hours of contact.

Moxidectin is a macrocyclic lactone used to prevent heartworm and treat a range of internal and external parasites. It works by disrupting nerve signal transmission in parasites, and is available in both oral and topical formulations.
Unknown ingredients refer to components listed in pet food formulations whose specific identity or source is not disclosed. These may originate from animal, plant, or synthetic sources. Their primary purpose can vary, including nutritional supplementation or functional roles such as preservation. As their exact form is unspecified, it is unclear whether they are used in their natural state or as processed compounds, raising concerns about transparency and traceability.
This ingredient is included as a cost-effective component or processing aid, potentially serving to optimise manufacturing efficiency or product texture. Its presence may also support labelling requirements or contribute to the product’s stability, though its specific functional role is not clearly defined.
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